The Development of an Electrochemotherapy Patient Tool to Assess Patient Experiences of Electrochemotherapy in the Treatment of Cutaneous Malignancies

There are no specific scales to assess patients quality of life or overall experience following electrochemotherapy (ECT). The aim of this study is to design an Electrochemotherapy Patient Assessment (EPA) questionnaire that assesses patient experience of ECT including any side effects. Sixty two patients with cutaneous malignancies who were registered in an ECT trial at Cork University Hospital were invited to pa...

Telotristat Ethyl for Treatment of Carcinoid Syndrome

Introduction: Carcinoid syndrome affects quality of life and prognosis of patients with neuroendocrine neoplasia. Diarrhea and flushing are the most frequent symptoms. Standard treatment of carcinoid syndrome is somatostatin analogs. However, during course of the disease, a significant proportion of patients become treatment resistant. Telotristaethyl is the first in his class medication inhibiting peripheral sero...

Clinical Relevance of Co-Expression of HLA-DRα, CD74/II and NFkB in Epithelial Ovarian Cancer: Identification of Prognostic and Therapeutical Biomarker Profile

Purpose: Ovarian Cancer (OVCA) is the gynecologic malignancy of highest lethality rate. We’ve demonstrated that HLA-DRA, HLA-DRB and CD74/Ii, which code HLADRa, HLA-DRb and invariant chain of HLA-DR complex are over expressed in OVCA and other cancers. Nevertheless, HLA-DRb is suppressed in OVCA. Furthermore, CD74/Ii might interact with NFkB, a molecule related to cellular proliferation, angiogenesis, metastasis a...

Extramedullary Precursor B-Cell Lymphoblastic Leukemia: A Rare Presentation & Opportunity?

Renal presentation of the B-cell acute lymphoblastic leukemia is extremely rare. We are presenting such a case. B lymphoblastic leukemia/lymphoma (B-ALL/LBL) accounts for 2% of lymphoid neoplasms diagnosed in the United States. B-cell acute lymphoproliferative disease manifest as pure leukemia (B-ALL) in 80% of cases, isolated extramedullary disease (B-LBL) in 10% and mixed B-ALL/B-LBL in 10% of cases.

Squamous Cell Carcinoma of the Rectum

Renal presentation of the B-cell acute lymphoblastic leukemia is extremely rare. We are presenting such a case. B lymphoblastic leukemia/lymphoma (B-ALL/LBL) accounts for 2% of lymphoid neoplasms diagnosed in the United States. B-cell acute lymphoproliferative disease manifest as pure leukemia (B-ALL) in 80% of cases, isolated extramedullary disease (B-LBL) in 10% and mixed B-ALL/B-LBL in 10% of cases.

Diagnostic Yield of Upper Gastrointestinal Endoscopy with reference to Barrett’s Esophagus in a Tertiary Care Center in India

Background: Upper gastrointestinal (GI) endoscopy is a common diagnostic procedure that plays central role in gastroenterology. It is a safe, accurate open access investigation for evaluation of wide range of upper GI lesions. The study was aimed to know the diagnostic yield of upper GI endoscopy in patients with GI symptoms. We focused to investigate the prevalence, clinical features, risk factors and endoscopic...

Advanced Bio-inspired Point of Care for Skin Cancer Early Detection

Background: The early detection of melanoma significantly affects the estimated 5-year survival rate of patients. The traditional manual visual methods used in the clinical screening suffer from clinician subjectivity, low sensitivity and specificity. Materials and Methods: Amethod based on a combined approach that employs ad-hoc customised innovative hand-crafted image features together with a feed-forward Levenb...