Perineal Groove: More than a Rare Anomaly Review of the Literature

The perineal groove is a rare congenital malformation that mainly affects females. Stephens and Smith first described it in 1968 as a moist groove between the vulvar fork and the anus without alteration of the vestibule, urethral or vaginal introitus, and hypertrophy of the labia minora bordering the groove posteriorly to join or surround the anus. Perineal groove is usually asymptomatic and with spontaneous resol...

Hypothesis on the use of Galactose in Prolonged Cardiac Arrest to Restore Neuronal Bioenergetics

Cardiac arrest survivors are prone to brain injury, secondary to ischaemia/reperfusion. Several studies on both human and animal models have shown an association among intra-arrest hyperglycemia and poor neurological recovery. However, the optimal blood glucose levels have not been established by the 2020 American Heart Association Guidelines for Advanced Cardiac Life Support. Glucose can become harmful for the br...

Directly Filtering the Sparse-View CT Images by BM3D

The x-ray Computed Tomography (CT) images with sparse-view data acquisition contain severe angular aliasing artifacts. The common denoising filters do not work well if they are used to reduce the artifacts. The state-of-the-art methods to process the sparse-view CT images are deep-learning based; they require a large amount of training data pairs. This paper considers a situation where no clinical training data se...

Detection of Sickle Cell Trait and Dengue Virus Serological Markers in Blood Bags: A Challenge in the Management of Persons Affected by Sickle Cell Disease

Background: Blood transfusions still remains the cornerstone in the management of sickle cell disease in African countries, hence the management of blood bags remains a public health concern. We aimed to determine the prevalence of the sickle cell trait and dengue virus serological markers in blood bags intended for transfusion to sickle cell patients. Methods: A cross-sectional survey was conducted at the Yaoundé...

The Effect of Far-Infrared Radiation on Waist Skin Surface Temperature, Meridian Resistance and Heart Rate Variability in Healthy Adults: A Quasi-Experimental Study

Background: In recent years Far-Infrared Radiation (FIR) meters are commonly used in home health care. In Traditional Chinese medicine, acupuncture is administered before far infrared radiation is applied to the patient. This study investigates the effects of FIR on the Waist Skin Surface Temperature (WSST), meridian resistance, and Autonomic Nervous System (ANS) activity to evaluate its effectiveness in reducing...

Bilateral Huge Congenital Diaphragmatic Hernia in a Neonate with Three Liver Lobes: A Case Report

Bilateral Congenital Diaphragmatic Hernia (CDH) is a birth defect with a rare occurrence. The neonates who are born with this defect are not able to survive to undergo the treatment. In this case report, we provide the details of anatomical abnormalities and changes in organ development observed in a male neonate with a huge diaphragmatic defect which was undiagnosed till after birth.

For they Know not What They do… Surgeons and Surgical Sutures

Incisional Hernia (IH) formation is the complication in abdominal surgery most often requiring re-operation and has a considerable medical and socio-economic impact. Efforts to reduce IH incidence have mainly focused on suture material and suture technique in the last 50 years and have to be judged as ineffective. This review has its focus on the surgeon as an underestimated risk factor for IH formation and the ef...

Osteopontin 9250 C/T Gene Polymorphism in Egyptian Lupus Nephritis Patients

Objective: To investigate the possible association of osteopontin 9250 C/T (rs 1126616) SNP with the development of lupus nephritis among a cohort of Egyptian lupus patients and evaluate its correlation with laboratory and clinical data in addition to both activity and chronicity indices (according to NIH). Methods: Detection of osteopontin 9250 C/T (rs 1126616) SNP for 100 lupus nephritis patients and 100 control...

Diagnostic Approaches of Duchenne Muscular Dystrophy (DMD): One Critical View

Muscular dystrophy is a genetic disease and characterized by progressive muscle wasting and weakness with variable distribution and severity. Duchenne Muscular Dystrophy (DMD) is a lethal and the most rapidly progressive forms of dystrophy. Clinical symptoms in DMD patients are started in between the age of 3-5 years. These are difficulty in standing, walking, running and climbing the stairs. Frequent falls are al...

Hemophilic Arthropathy: Basic Records for Proper Joint and Musculoskeletal Health Care in Patients with Hemophilia

Hemophilia is a genetic disease, classified as a rare disease and affects approximately 1 in every 5,000 live births male. It is classified as severe, moderate and mild depending on the percentages of plasma circulating coagulation factors. It is characterized by hemorrhagic episodes that, in the absence of treatment, occur spontaneously in muscles and joints, causing hemophilic arthropathy and greatly influencing...

Lambdoid Diastasis Subsequent to Multisuture Craniosynostosis and Intracranial Hypertension in Osteopetrosis

Osteopetrosis is a rare disorder which is characterized by failure of osteoclasts to resorb bone minerals leading to thick and dense but fragile bone. Craniosynostosis is rare in patients with osteopetrosis which aggravates the severity of skull deformity and intracranial hypertension in these patients. Association of craniosynostosis with diastasis of open suture is uncommon. Here we report two patients with oste...

Manual Acupuncture Attenuates iNOS and TNF-Alpha Production and Modulates Stress Oxidative after Acute Seizures in Mice

The use of acupuncture in the treatment of Central Nervous System (CNS) disorders is an age-old practice. Although only a few studies have proven its efficacy, evidence has indicated the use of acupuncture to treat different types of seizures. Therefore, the present study aimed to evaluate the effect of Manual Acupuncture (MAC) using a chemical acute model. Also the effect of MAC on modulation of oxidative stress...

Study of Clinical Profile of 5 Cases of Inborn Errors of Metabolism in Critically Ill Children - In Tertiary Care Teaching Hospital Attached to Bangalore Medical College and Research Institute - Bangalore, Karnataka (India)

Introduction: Inborn Errors of Metabolism (IEM) are heterogeneous group of disorders caused due to single gene defect which may manifest immediately after birth or within few days or weeks after birth. A large number of Inborn Errors of Metabolism (IEM) in children remain undetected in India due to lack of investigative facilities and economic restraints. Most of the IEM result from defects in any of the key enzym...

Clinical Presentations and Treatment Outcomes of High Flow Malformations of the Lower Extremity

Objective: We aim to reveal real world data according to clinical presentations, radiological findings and treatment results of high flow vascular malformations of the lower extremity among patients in the AVM Register. Methods: We included all patients presenting with high flow malformations of the lower limb who were treated in Inselspital from 2008 to 2018; demographics, clinical presentations, radiological dat...

Clinical Features of Influenza in Healthcare Personnel and Non-Healthcare Personnel from 2009/10 to 2014/15: A Cross-Sectional Study at three University Hospitals

Purpose: The efficacy of the influenza vaccine in the 2014/15 season was lowover the past decade, and many healthcare personnel developed influenza at our medical facilities. To identify risk factors associated with influenza among health care personnel and non-healthcare personnel in the 2014/15 season and the past 5 years, we did a cross-sectional study at three university hospitals in Saitama prefecture, Japan....

Hypertension, Obstructive Sleep Apnea, and CPAP: A Literature Review

Cardiovascular Disease (CVD) is the leading cause of mortality and morbidity worldwide. Obstructive Sleep Apnea (OSA) remains an under diagnosed yet important risk factor for CVD and adverse cardiovascular out comes. There is a known link between untreated OSA and systemic hypertension, medicationresistant hypertension, and blood pressure variability. These clinical entities are independent risk factors for CVD an...